444 - Soft Probes for Bio-electrochemical Imaging by Tzu-En Lin

This book discusses the development of various reliable scanning electrochemical microscopy (SECM) imaging techniques for studying the distribution of biomarkers and nanomaterials in thin and thick animal samples, plant antioxidant (AO) defense systems, as well as human melanoma.

The authors demonstrate that SECM could improve the diagnosis and understanding of different melanoma stages on the basis of highly resolved maps of the tyrosinase distribution.

Tyrosinase is the key enzyme involved in fruit maturation and is a biomarker for melanoma. As such the book presents various tyrosinase SECM detection strategies developed for the analysis of the spatial distribution of tyrosinase in melanoma and in banana samples. It describes the first imaging of the redox active proteins within the entire mouse heart with an SECM system using a spider probe composed of eight independent microelectrodes. Further, it investigates distributions of injected graphene nanoribbons (GONRs) for drug delivery by Soft-Probe-SECM. Lastly, the book outlines a non-invasive electrochemical.

2019 | ISBN-10: 3030057577 | ID - 444

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* Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience:Volume 2

Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience: Volume 2: Microdialysis and Sensing of Neural Tissues by George S Wilson (Author, Editor), Adrian C Michael (Editor)

Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system.

It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques.

These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest.

Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered.

2017 | ISBN: 9813220538 | 62.4MB

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