Showing posts with label Genetics. Show all posts
Showing posts with label Genetics. Show all posts

Wednesday, March 25, 2020

N - 148 | The Lost Family: How DNA Testing Is Uncovering Secrets, Reuniting Relatives, and Upending Who We Are by Libby Copeland

A deeply reported look at the rise of home genetic testing and the seismic shock it has had on individual lives

You swab your cheek or spit in a vial, then send it away to a lab somewhere. Weeks later you get a report that might tell you where your ancestors came from or if you carry certain genetic risks. Or the report could reveal long-buried family secrets and upend your entire sense of identity. Soon a lark becomes an obsession, a relentless drive to find answers to questions at the core of your being, like “Who am I?” and “Where did I come from?” Welcome to the age of home genetic testing.

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Monday, March 16, 2020

SC - 1350 | Genes and Behaviour: Beyond Nature-Nurture

David J. Hosken, John Hunt, Nina Wedell

"Nature versus nurture" is a debate that refuses to die. This is perhaps due to the perceived political ramifications of the debate, but our understanding of the genetic basis of many behaviours has expanded markedly in the last 10 years, and there is now very good evidence that many seemingly complex behaviours can have relatively simple genetic underpinnings. We also know that behaviours, and other traits, are influenced not just by genes and the environment, but also by the statistical interaction between the two.


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Wednesday, March 11, 2020

SC - 1324 | ReCombinatorics: The Algorithmics of Ancestral Recombination Graphs and Explicit Phylogenetic Networks

Dan Gusfield

In this book, Dan Gusfield examines combinatorial algorithms to construct genealogical and exact phylogenetic networks, particularly ancestral recombination graphs (ARGs). The algorithms produce networks (or information about networks) that serve as hypotheses about the true genealogical history of observed biological sequences and can be applied to practical biological problems.


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Wednesday, February 26, 2020

SC - 1244 | CRISPR-Cas Systems: RNA-mediated Adaptive Immunity in Bacteria and Archaea

Francisco J. M. Mojica, Roger A. Garrett (auth.), Rodolphe Barrangou, John van der Oost (eds.)

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered.

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Saturday, December 21, 2019

SC - 1152 | A Century of Geneticists: Mutation to Medicine

A Century of Geneticists: Mutation to Medicine 1st Edition by Krishna Dronamraju (Author)

Genetics, like all scientific disciplines, is a human endeavor. Thus, the lives of geneticists - their friendships, colleagues and associations - play an important role in the historical development of the science.

This book summarizes the history of genetics by reviewing the lives of the prominent and influential researchers beginning with the earliest and simplest branches of genetics (studies of inheritance and mutation) and ending with the human genome project - the pinnacle of genetics research of the 20th century.

2019 | ISBN-13: 978-1-4987-4866-7 | ISBN-13: 978-1-138-35313-8 | ID: SC - 1152

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Sunday, August 25, 2019

243 - Host-Fungus Interactions

Host-Fungus Interactions: Methods and Protocols 2012th Edition by Alexandra C. Brand, Donna M. MacCallum

Microbiologists, medical mycologists, immunologists, and biochemists are increasingly working together to focus on the processes involved in the progression and treatment of fungal disease.

Host-Fungus Interactions: Methods and Protocols is designed for research scientists who are involved in this work and interested in undertaking new or comparative studies of interactions between the mammalian host and clinically important fungal pathogens.

Aiming to combine approaches for reverse genetics in pathogenic fungi with methods for their application in in vitro and in vivo models of disease, the book includes methods for the culture and genetic manipulation of the primary fungal pathogens and the opportunistic pathogens, as well as methods for investigating host-fungus interactions in model systems.

Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

2012 | ISBN: 9781617795381 | ID - 243

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247 - Therapies for Children With Autism Spectrum Disorder

Therapies for Children With Autism Spectrum Disorder: Behavioral Interventions Update by Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services

Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by impaired social communication and social interaction accompanied by atypical patterns of behavior and interest.

ASD is differentiated from other developmental disorders by significant impairments in social interaction and communication, along with restrictive, repetitive, and stereotypical behaviors and activities.

Social communication and social interaction features include deficits in social-emotional reciprocity (e.g., deficits in joint attention, atypical social approach and response, conversational challenges, reduced sharing of interest, emotions, and affect); deficits in nonverbal communication (e.g., atypical eye contact, reduced gesture use, limited use of facial expressions in social interactions, challenges understanding nonverbal communication); and deficits in forming and maintaining relationships (e.g., diminished peer interest, challenges joining in play, difficulties adjusting behavior to social context).

ASD features of restricted repetitive patterns of behavior, interests, or activities may include stereotyped motor mannerisms, use of objects, or speech (e.g., simple motor stereotypies, repetitive play, echolalia, and formal or idiosyncratic speech); insistence on sameness, inflexible adherence to routines, or ritualized patterns of behavior (e.g., distress at small changes, rigid patterns of thought and behavior, performance of everyday activities in ritualistic manner); intense preoccupation with specific interests (e.g., strong attachment to objects, circumscribed or perseverative topics of interest); and sensory sensitivities or interests (e.g., hyperreactivity or hyporeactivity to pain and sensory input, sensitivity to noise, visual fascination with objects or movement).

ASD symptoms cause impairment across many areas of functioning and are present early in life. However, impairments may not be fully evident until environmental demands exceed children’s capacity. They also may be masked by learned compensatory strategies later in life. Many children with ASD may also have intellectual impairment or language impairment, and the disorder may be associated with known medical, genetic, or environmental factors. Treatments for ASD that families pursue include behavioral, educational, medical, allied health, and complementary approaches. Individual goals for treatment vary for different children and may include combinations of therapies.

For many individuals, core symptoms of ASD (impairments in communication and social interaction and restricted/repetitive behaviors and interests) may improve with intervention and over time; however, deficits typically remain throughout the lifespan. Lifelong management—often using multiple treatment approaches—may be required to maximize functional independence and quality of life.

This systematic review updates the behavioral intervention portion of our comprehensive review of therapies for children with ASD published in 2011. ASD intervention categories overlap substantially, and it can be difficult to cleanly identify the category into which an intervention should be placed. Ultimately, we defined behavioral interventions to include early intensive behavioral and developmental interventions, social skills interventions, play/interaction-focused approaches, interventions targeting symptoms commonly associated with ASD, and other general psychosocial approaches.

This behavioral category of intervention explicitly does not include primarily medical interventions, complementary and alternative interventions, allied health interventions, or educationally focused interventions unless a behavioral intervention representative of the operationalization above was included within the study design.

2015 | ISBN: 9781508794578 | ID - 247

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248 - Fusion Genes and Cancer

Fusion Genes and Cancer 1st Edition by Ajaikumar B. Kunnumakkara, Ganesan Padmavathi, Nand Kishor Roy

Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis.

Concept of 'fusion genes' seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic.

Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date.

2017 | ISBN: 9789813200937 | ID - 248

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249 - DJ-1/PARK7 Protein

DJ-1/PARK7 Protein: Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases 1st ed. 2017 Edition by Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases.

The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD.

The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility.

Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.

2017 | ISBN: 9789811065828 | ID - 249

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254 - Neuroviral Infections: General Principles and DNA Viruses

Neuroviral Infections: General Principles and DNA Viruses by Sunit K. Singh (Editor), Daniel Ruzek (Editor)

Viral infections of the central nervous system or neurotropic viruses are often lethal. Understanding of these diseases involves understanding the interaction between the nervous system and the immune system.

This book provides in-depth information about each individual virus, the diseases they cause, and the mechanisms of spread of those diseases.

Addressing both clinical and basic science aspects, the text covers such diseases as polio, measles, rabies, herpes, West Nile, Japanese encephalitis, and varicella-zoster. The authors also include detailed discussions of molecular pathogenesis and host pathogen immune interaction as well as disease detection, treatment, and prevention.

2013 | ISBN: 1466567198 |  ID - 254

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260 - Crohn's and Colitis

Crohn's and Colitis: Understanding and Managing IBD by Hillary Steinhart (Author)

A newly updated edition from one of the most respected and authoritative experts on Crohn's and colitis.

For anyone who suffers from Crohn's disease or ulcerative colitis, an understanding of inflammatory bowel disease is the key to developing effective management strategies. Crohn's and Colitis aims to help patients deepen their knowledge about their disease, and it has been recognized by practitioners and patients alike for its invaluable information and its supportive and easy-to-follow approach. It has long been a market leader, with over 30,000 copies sold.

This new edition is poised to continue the trend. It features updated content based on the most current research and standards for diagnosis and treatment, along with information on genetics-based drugs and naturopathic treatments. It is a valuable tool for improving quality of life for anyone diagnosed with inflammatory bowel disease.

Crohn's and Colitis also includes information on underlying causes, clinical features and effective treatments. With informative charts, case studies, "Did You Know?" boxes and answers to frequently asked questions, this book truly aims to help patients improve their health and well-being in a way that is friendly and accessible.

2018 | ISBN: 0778806197 |  ID - 260

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* Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 9th Edition by John P. Bilezikian (Editor)

The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated.

Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic.

With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.

The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health.

This vital resource:

Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science
Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers
Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics

Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

2018 | ISBN: 1119266564 |  *

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278 | Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy: Causes, Treatment and Research (Cardiology Research and Clinical Developments) by Ikram Kammoun (Editor)

Hypertrophic cardiomyopathy (HCM) is the most common form of genetically inherited cardiovascular disease, with a prevalence of one in 500 individuals.

Hypertrophic cardiomyopathy is characterized by both increased ventricular wall thickness in the absence of other causative conditions and potentially fatal arrhythmias.

Tunisian authors, together with recognized specialists in this field from Italy, France, and Austria, offer a broad and detailed discussion of diagnosis, risk stratification and management of HCM.

This book describes recent advances in genetics which provide screening options for affected families, making it essential for modern cardiologists to understand the diagnostic, therapeutic, and prognostic implications of HCM genetic testing. The diagnostic and prognostic role of cardiac imaging in HCM, with reference to echocardiography and cardiac magnetic resonance, is detailed within this book as well. The greatest challenge in the management of HCM is identifying individuals who are at an increased risk of sudden cardiac death.

This book offers an overview of the most recent data available concerning this stratification. The obstructive form of HCM is also dealt with in this book with a description of the different catheter-based techniques for septal reduction. Finally, the topic of management of pregnant women with HCM is addressed.

2018 | ISBN-10: 1536130036 |  ID - 278

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Saturday, August 24, 2019

* Chemistry in Context by American Chemical Society

Following in the tradition of the first eight editions, the goal of this successful, issues-based textbook, Chemistry in Context, is to establish chemical principles on a need-to-know basis for non-science majors, enabling them to learn chemistry in the context of their own lives and significant issues facing science and the world.

The non-traditional approach of Chemistry in Context reflects today's technological issues and the chemistry principles within them. Global warming, alternate fuels, nutrition, and genetic engineering are examples of issues that are covered in Chemistry in Context.

2018 | ISBN: 1259638146 |  113MB

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Friday, August 23, 2019

326 - Plant Transposable Elements: Methods and Protocols

Plant Transposable Elements: Methods and Protocols (Methods in Molecular Biology) by Thomas Peterson (Editor)

Transposable elements have played a major role in shaping plant genome structure and gene expression. Transposons not only drive sequence expansion, induce mutations and generate chromosome rearrangements, they also help to shape the epigenetic topology of the eukaryotic genome.

In Plant Transposable Elements: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study transposons. These methods include computational approaches to study the ancient transposon remnants that comprise the bulk of plant genomes, as well as laboratory techniques to identify recent and ongoing transposition events.

Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Plant Transposable Elements: Methods and Protocols seeks to aid scientists in the further study of transposons by providing essential background information and specific experimental protocols.

2013 | ISBN: 1627035672 |  ID - 326

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335 - Array Comparative Genomic Hybridization

Array Comparative Genomic Hybridization: Protocols and Applications (Methods in Molecular Biology) by Diponkar Banerjee (Editor), Sohrab P. Shah (Editor)

The earliest descriptions of human chromosomes initiated the genomics revolution that is now upon us.
This book explores the scope of what is now possible as far as documenting abnormalities associated with several human cancers.

While the technology for interrogating the human genome continues to evolve, refinement of comparative genomic hybridization (CGH) using array CGH and related technologies have provided enormous insight into human cancers at an affordable scale.

2013 | ISBN: 1627032800 |  ID - 335

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347 - Fundamentals of Food Biotechnology by Byong H. Lee

Food biotechnology is the application of modern biotechnological techniques to the manufacture and processing of food, for example through fermentation of food (which is the oldest biotechnological process) and food additives, as well as plant and animal cell cultures.

New developments in fermentation and enzyme technological processes, molecular thermodynamics, genetic engineering, protein engineering, metabolic engineering, bioengineering, and processes involving monoclonal antibodies, nanobiotechnology and quorum sensing have introduced exciting new dimensions to food biotechnology, a burgeoning field that transcends many scientific disciplines.

Fundamentals of Food Biotechnology, 2nd edition is based on the author's 25 years of experience teaching on a food biotechnology course at McGill University in Canada. The book will appeal to professional food scientists as well as graduate and advanced undergraduate students by addressing the latest exciting food biotechnology research in areas such as genetically modified foods (GMOs), bioenergy, bioplastics, functional foods/nutraceuticals, nanobiotechnology, quorum sensing and quenching. In addition, cloning techniques for bacterial and yeast enzymes are included in a "New Trends and Tools" section and selected references, questions and answers appear at the end of each chapter.

This new edition has been comprehensively rewritten and restructured to reflect the new technologies, products and trends that have emerged since the original book. Many new aspects highlight the short and longer term commercial potential of food biotechnology.

2015 | ISBN: 1118384954 | ID - 347

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* Invertebrates

Invertebrates by Richard C. Brusca, Wendy Moore, Stephen M. Shuster (Author)

In the twelve years since publication of Invertebrates, Second Edition, fundamental shifts have occurred in our understanding of the origins and evolutionary relationships among protists and animals. These changes are largely due to the explosion of molecular phylogenetics and evo-devo research, emergence of the new field of animal genomics, major fossil discoveries in China, Australia, and elsewhere, and important new embryological and ultrastructural studies.

As a result:

- New phyla have been described (e.g., Micrognathozoa, Xenacoelomorpha).
- Old phyla have been collapsed into others (e.g., Sipuncula and Echiura are now placed within Annelida; acanthocephalans are now known to be highly modified, parasitic rotifers).
- Phyla once thought to be deuterostomes are now part of the protostome clade (e.g., Chaetognatha, Phoronida, Bryozoa, Brachiopoda).
- The Protostomia has been reorganized into two major clades known as Ecdysozoa and Spiralia.

For each of the thirty-two currently recognized phyla, Invertebrates, Third Edition, presents detailed classifications, revised taxonomic synopses, updated information on general biology and anatomy, and current phylogenetic hypotheses, organized with boxes and tables, and illustrated with abundant line drawings and new color photos.

The chapters are organized around the "new animal phylogeny," while introductory chapters provide basic background information on the general biology of invertebrates. Two new coauthors have been added to the writing team, and twenty-two additional invertebrate zoologists have contributed to chapter revisions. This benchmark volume on our modern views of invertebrate biology should be in every zoologist's library.

2016 | ISBN: 1605353752 | 119MB

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351 - Extracellular Matrix in Development and Disease by Julia Thom Oxford

The extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body.

The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection.

2019 | ISBN : 3038975702 | ID - 351

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352 - One Plus One Equals One

One Plus One Equals One: Symbiosis and the evolution of complex life by John Archibald (Author)

We are in the midst of a revolution. It is a scientific revolution built upon the tools of molecular biology, with which we probe and prod the living world in ways unimaginable a few decades ago. Need to track a bacterium at the root of a hospital outbreak? No problem: the offending germ's complete genetic profile can be obtained in 24 hours. We insert human DNA into E. coli bacteria to produce our insulin.

2014 | ISBN: 019966059X | ID - 352

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